منابع مشابه
Clinical Evaluation of New Drugs
The explosive increase in the number of drugs offered for therapy has had many consequences, one of which is to increase the amount of testing that must be done in man. The large number of such studies makes it more urgent that the physician be reminded of his responsibilities in such a program and that he be knowledgeable about the methods for carrying out clinical trials so that the fewest nu...
متن کاملSedative-Hypnotic and Anxiolytic Drugs
The primary use of sedative–hypnotic and anxiolytic drugs is to encourage calmness (anxiolytics or sedatives) or to produce sleep (sedative–hypnotics). All people are subject to states of emotional tension and uneasiness. For otherwise healthy individuals, these occasions are usually sufficiently mild and short that pharmacological intervention is unnecessary. However, at times the symptoms of ...
متن کاملSeparation of Sedative – Hypnotic Drugs with Mixed Micellar Liquid Chromatography
Separation of ten sedative- hypnotic drugs was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, type and amount of organic modifier in mobile phase on efficiency (N) and asymmetry factor (B/A) showed that, the appropriate conditions for a good separation were 35°C and 7% (V/V) butanol in mobile phase. Variations of selectivity factor versus butanol concent...
متن کاملCLINICAL PROGRESS Clinical Evaluation of Antihypertensive Drugs
T HE evaluation of antihypertensive drugs has become a big business. Hundreds of people who work in some aspect of clinical investigation spend at least part of their time in this process. Their observations determine the expenditure, first by the drug companies and then by the public, of some millions of dollars a year. Even the law recognizes the fact that no accumulation of pharmacology, how...
متن کاملseparation of sedative – hypnotic drugs with mixed micellar liquid chromatography
separation of ten sedative- hypnotic drugs was performed by rp-hplc using mixed micellar mobile phase. effect of temperature, type and amount of organic modifier in mobile phase on efficiency (n) and asymmetry factor (b/a) showed that, the appropriate conditions for a good separation were 35°c and 7% (v/v) butanol in mobile phase. variations of selectivity factor versus butanol concentration, ...
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ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1972
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03005039